TYMS and non-small cell lung carcinoma: In recent years, a number of genes related to the prognosis and chemotherapy efficacy of NSCLC have been found, such as ERCC1 (excision repair cross complementary gene 1), RRM1 (ribonucleotide reductase M 1), BRCA1 (breast cancer susceptibility gene 1), TS (thymidylate synthase), and p53 protein [19,20,21,22,23].