EGFR and head and neck squamous cell carcinoma: In the present study, we compared cytotoxicity of six anti-HER1 CAR-NK-92 cell variants, generated primary HNSCC (pHNSCC) cell lines and demonstrated effective elimination of pHNSCC cells as well as SCC cell lines by our anti-HER1 CAR-NK-92 cells in 2D and 3D models.