In another study, by Nakano et al., the uses of exosomal miR-92b and circulating AFP were compared among patients with LT HCC; it was found that the exosome predicted the early recurrence of HCC with an AUC of 0.925 (95% CI 0.86–0.98; sensitivity 85.7%, specificity 86%), while the AUC of the AFP was 0.612 (95% CI 0.49–0.73; sensitivity 92.9%, specificity 38.5%) [118]. The gene discussed is AFP; the disease is hepatocellular carcinoma.