In an analysis of 107 HCC patients, almost 60% had at least one single-nucleotide variation, with MutL homolog 1 (13%), serine/threonine kinase 11 (13%), phosphatase and TENsin homolog (9%), and catenin beta 1 (4%) the four most frequent sites [119]. Here, CTNNB1 is linked to hepatocellular carcinoma.