When considering HCC as a whole, there is no clearly dominant mutational pathway; however, many of the mutations converge with the same main oncologic pathways, such as the p53-signaling pathway, telomerase maintenance, CTNNB1 (catenin-cadherin-associated protein, beta1), vascular endothelial growth factor (VEGF), and changes in response to oxidative stress [104,105,106,107,108,109]. The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.