They demonstrated that six ARGP signatures consisting of BAK1/PELP1, BIRC5/CDKN2A, BIRC5/RGS19, CAPN2/ULK3, DIRAS3/TMEM74 and PRKCD/RB1CC1 could categorize HCC patients into two distinct subgroups, demonstrating a significant difference in the overall survival (OS) [106]. The gene discussed is BIRC5; the disease is hepatocellular carcinoma.