Recent studies have suggested that NASH-related HCC may be less responsive to immunotherapy due to the presence of CD8+ T cells, particularly the CXCR6+ subset induced by hepatic steatosis, which can cause hepatocyte injury and inflammation through the secretion of proinflammatory cytokines and tumor necrosis factor (TNF) [119]. The gene discussed is TNF; the disease is hepatocellular carcinoma.