(1) whereas adaptive immune responses to adenoviral coat proteins may rapidly inactivate any injected TAV255 virus that reaches the circulation, encapsulated TAV255 is likely to be more resistant to antibody neutralization and thus may “seed” the uninjected tumor site target and draw in an immune response and (2) because encapsulated virus more efficiently infects the injected tumor, it may stimulate systemic antitumor immunity more effectively in the absence of viral seeding of the uninjected tumor which the observation of greater cytotoxic T cell infiltration supports. Here, GOLPH3 is linked to neoplasm.