However, although the loss of chromosome 9p21 is associated with poorer patient survival, 9p21 loss of heterozygosity was shown by Baietti et al. [59] to not lead to decreased expression of CDKN2A, suggesting alternative mechanisms of 9p-mediated tumorigenesis; indeed, in this latter work, 9p21 loss was shown to relieve the HOXB13 (homeobox gene 13) locus, promoting its expression, and thus tumor cell growth, which is associated with poorer survival of ccRCC patients. The gene discussed is CDKN2A; the disease is neoplasm.