The two miRNAs (hsa-mir-221-3p and hsa-mir-30a-5p) showed a higher degree and betweenness of the centrality levels, and their targets (TP53, CTNNB1, UBC, TRIM28, and HDAC1) seem to play a more critical role in GBM than others. Here, HDAC1 is linked to glioblastoma.