Based on the biological pathways, the identified genes in the GBM biomarker panel were classified into different signaling pathways such as the AKT (MYC, BMI1, EGFR, PIK3CA, PTK2, and UBC), the inflammation (IRAK1 and APP), the P53 (HDAC1, P53, and TRIM28), the WNT (CTNNB1), and the mitochondrial signaling pathways (DAB1, PINK1, and RELN). The gene discussed is RELN; the disease is glioblastoma.