In an Asian cohort with long-term follow-up, Shiina et al. also demonstrated RFA could be locally curative with survival up to 10 years, and the OS was influenced by age, antibody to hepatitis C virus (anti-HCV), Child-Pugh class, tumor size, tumor number, serum α-fetoprotein (AFP) level, serum des-γ-carboxy-prothrombin (DCP) level, and serum lectin-reactive α-fetoprotein level (AFP-L3) [5]. The gene discussed is AFP; the disease is neoplasm.