Lastly, EMT processes in high-grade glioma and pilocytic astrocytoma were simultaneously discovered, but higher EMT activities correlated with a higher grade of tumours and worse prognoses for the patients, while the existence of apparent aggressive glioblastoma subtypes with high E-cadherin expression [135,136] caused experts in the field to rethink EMT/MET in tumour aggressiveness. The gene discussed is CDH1; the disease is central nervous system cancer.