In later studies, the driver mutations of ZFTA (RELA) fusion and YAP1 fusion were both confirmed to contribute to the oncogenic signalling by inducing neural progenitor cells or neural stem cells to form ependymomas [67,68], and single-cell RNA sequencing revealed subgroups of tumour cells called undifferentiated ependymal cells (UECs) that might act as CSCs in ependymomas, since their RNA profile overlapped with most of progenitors in different lineages, with spatiotemporally specific signatures in separating CSCs of supratentorial and anteroposterior ependymoma [35,36]. This evidence concerns the gene YAP1 and ependymoma.