SHH and neoplasm: Atypical teratoid/rhabdoid tumours (AT/RT) have been divided into three molecular subtypes, TYR, SHH, and MYC, which predominantly affect infants or young children, with a remarkably simple alteration of SWItch/sucrose nonfermentable related, Matrix-associated, Actin-dependent regulator of Chromatin, Subfamily B1 (SMARCB1) or SMARCA4, but with devastating outcomes [73].