For example, the dysregulation of embryonal development pathways SHH, WNT, and NOTCH, or the alteration of the proto-oncogenic tumour suppressor Retinoblastoma protein (Rb) oncogene Rb, are commonly seen in paediatric embryonal CNS tumours and are rarely seen in adult CNS tumours; CSCs from embryonic stem cells, neural crest cells, and neural stem cells can form embryonal tumours, while those from less pluripotent neural stem cells and neuronal/glial progenitor cells mainly form malignant gliomas [80,152]. This evidence concerns the gene SHH and central nervous system neoplasm.