The mouse model confirmed that the SHH subgroup medulloblastoma arose from both granule neuron precursors (GNPs) and multipotent neural stem cells, by CSC markers of p75NTR, TrkC, Zic1, MATH1, SOX1, SOX2, PLZF, DACH1, Multimerin 1, PAX6, ATOH1, MycN, and differentiation markers of NeuN, GABRA6, Synaptophysin, PAX2, BLBP, and O4 [40,41]. This evidence concerns the gene SOX2 and medulloblastoma.