After the first report of isolating CSCs of AT/RT from patients by a marker of CD133 through sphere culture and a xenograft model [43], SMARCB1-deficient pluripotent stem cells-based experiments revealed that the origin of CSCs in AT/RT, SMARCB1-deficient neural progenitor-like cells efficiently gave rise to AT/RT-like tumours and their stemness signatures worsened the prognosis [46]. This evidence concerns the gene SMARCB1 and neoplasm.