CNS Ewing sarcoma belongs to the catalogue of mesenchymal, non-meningothelial tumours, driven by EWS gene fusions, which might originate from mesenchymal stem cells since their CSCs are confirmed by CD44, CD59, CD73, CD29, and CD54, CD90, CD105, and CD166, with differentiation markers of chondrocyte lineage-SOX9, COL10A1, PPARg2, FABP4, LPL, and osteogenic differentiation SPP1, ALPL, and RUNX2 [60]. The gene discussed is CD44; the disease is neoplasm.