Interestingly, Lopez-Soto and colleagues [147] showed that induction of EMT in colorectal cancer cells via SNAIL overexpression induced upregulation of the NKG2D ligands MICA/B and ULBP2, suggesting an avenue for NKG2D-mediated natural killer (NK) cell immunotherapy [148]. This evidence concerns the gene SNAI1 and colorectal cancer.