Significant findings in this study are: (1) Compared to normal tumor tissues, SGK1 protein expression was higher in breast cancer tissues, especially in ER/PR negative and triple-negative tumors; (2) Bcl-2 protein expression was lower in breast cancer than normal breast tissues; (3) higher Bcl-2 expression was associated with hormone receptor positivity, lower tumor grade, and earlier stages; longer survival (4) Bcl-2 protein expression was lower in women who self-reported as African American compared to Hispanic and nH White women. This evidence concerns the gene ESR1 and neoplasm.