SOX2 and colorectal carcinoma: Accordingly, DDX27 depletion restrained the expression of OCT4, Nanog, Sox2, ALDH1A1, CRC cell migration, invasion, and EMT, reduced sphere formation efficiency and the number of CD133-positive cells; however, these changes could be counteracted by circUHRF2 overexpression (Supplementary Figure S2C–K).