Notably, the authors observed a significant increase in the densities of CD3+ and CD8+ T cells in the tumor specimens of LTS patients, which was positively correlated with the tumor microbiome diversity and specific bacterial genera (i.e., Saccharopolyspora, Pseudoxanthomonas, and Streptomyces) and was ultimately associated with better overall survival [44]. Here, CD8A is linked to neoplasm.