Specifically, we identified a novel panel of reciprocal miRNA–mRNA pairings involved in AA PCa aggressiveness, including miR-133a/MCL1 (down/up), miR-513c/STAT1 (down/up), miR-145/ITPR2 (down/up), miR-34a/PPP2R2A (down/up), miR-34a-5p/HIF1A (down/up), miR-34a-5p/PIK3CB (down/up), miR-34a-5p/IGFBP2 (down/up), miR-99b-5p/MTOR (down/up), miR-96-5p/FOXO3A (up/down), and miR-96-5p/MAPKAPK2 (up/down) [45,217]. This evidence concerns the gene PIK3CB and posterior cortical atrophy.