The percentages of CD4+ memory resting T-cells, CD4+ memory activated T-cells were lower in CRC tumours with upregulated B7H3 expression, while conversely an increased fraction of regulatory T-cells (Tregs), monocytes, macrophages M0, eosinophils and neutrophils was associated with higher B7H3 expression (Figure 12). Here, CD4 is linked to neoplasm.