In several studies, B7H3 was proven to play a crucial role not only in evasion from immune surveillance but also in non-immune processes promoting malignancy progression, such as epithelial-mesenchymal transition, chemoresistance, cell survival, migration and invasion, which makes B7H3 an even more appealing therapeutic target for CRC [27,34]. Here, CD276 is linked to colorectal carcinoma.