The main results of our meta-analysis on 20 primary-level studies and 2451 patients with OSCC point out that pRb expression is a factor which improves survival of patients with oral cancer (HR = 0.79, 95CI% = 0.64–0.98, p = 0.03), this data indicates that patients with oral cancer who lose pRb expression survive 1.27 times more than patients who maintain gene and protein function. The gene discussed is RB1; the disease is lip and oral cavity carcinoma.