We showed that doxorubicin/GTN treatment of tumor PMN-MDSCs partially alleviates their immunosuppressive activity on CD8 TILs, evidenced by the increase in CD8 TILs proliferation when co-cultured with doxorubicin/GTN-treated-PMN-MDSCs, compared to their proliferation when co-cultured with control PMN-MDSCs (Figure 3E). Here, CD8A is linked to neoplasm.