The novel Δ14Δ16 UTX mRNA isoform ranged from 19% in RPE-1 to 51% in the colorectal carcinoma cell line, COLO205, whereas the novel Δ16 isoform was less abundant and ranged from 1% to 6% (Figure 2A). The gene discussed is KDM6A; the disease is colorectal carcinoma.