In a comparative analysis study of RNA sequencing data from AR+ LNCaP PCa cell line versus AR− PC3 PCa cell line, IL-1 signaling genes were found to be overly expressed in LNCaP cells but constitutively expressed in PC3 cells [200], thus showing that IL-1 cytokines signaling through MyD88 and IRAK1/4 adapters contribute to PCa cell survival and tumorigenicity in an inflammatory tumor microenvironment. The gene discussed is IL1A; the disease is neoplasm.