An NF-κB inhibitor called parthenolide has been shown to significantly induce apoptosis in both CD133+ CSC and normal progenitor cells [271], thus implying that the transformation of SCs to CSCs in the prostate may be a critical process in the initiation of PCa, and this transformation could be impacted or enhanced by the pro-tumorigenic effects of chronic inflammatory signals [272]. Here, NFKB1 is linked to posterior cortical atrophy.