The contributions of many of these inflammatory signaling activators (TLRs, MYD88, TRIF, IL1R1, IRAK1/4, TRAF6, and NF-κB) and suppressors (IRAK3, TOLLIP, SOCS1, RNF216, IL1RL1, IL36RN, and TNFAIP3) in PCa remain poorly studied, despite the increasing association in the scientific literature of chronic inflammation with PCa initiation, progression, immunosuppression, and therapy resistance [301]. The gene discussed is IRAK3; the disease is posterior cortical atrophy.