Brain edema (HR = 12.76, 95% CI = 1.76–92.57, p = 0.012) and MIB-1 index ≥5% (HR = 7.25, 95% CI = 1.11–47.20, p = 0.038) were also found to be significantly associated with shortened PFS. The gene discussed is MIB1; the disease is brain edema.