For example, anthracyclines and oncolytic viruses induce immunogenic cell death (ICD) in which dying tumor cells release or express danger-associated molecular patterns (DAMPs) such as calreticulin (CRT), High Mobility Group Box-1 (HMGB-1), and heat shock proteins (HSP-70 and HSP-90) [16]. Here, HMGB1 is linked to neoplasm.