TGFB1 and cancer: Through immunogenomic analysis of over 10,000 tumors from 33 cancer types available from TCGA, one group identified six major subtypes of the immune landscape of cancer: Wound healing (C1), IFN-γ dominant (C2), inflammatory (C3), lymphocyte depleted (C4), immunologically quiet (C5), and TGF-β dominant (C6) [47].