Moreover, we found that overexpression/knockdown of UBQLN1 promoted/inhibited the proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT) of CRC cells in vitro and knockdown of UBQLN1 inhibited CRC cell’s tumorigenesis as well as metastasis in vivo. This evidence concerns the gene UBQLN1 and colorectal carcinoma.