NE-SCLC neoplasms include tumors expressing the transcription factor ASCL1 (SCLC-A) or NEUROD1 (SCLC-N), whereas non-NE tumors express POU2F3 (SCLC-P) or YAP1 (SCLC-Y) [174]. The gene discussed is NEUROD1; the disease is small cell lung carcinoma.