Serum S100B protein is a moderately sensitive—61.35% (95% Confidence Interval (CI) (48.90, 73.80) and highly specific—87.30% (95% CI (81.10, 93.49)) melanoma recurrence biomarker, but because increased levels of S100B can result from several other conditions (cardiovascular disease, chronic kidney disease, liver cirrhosis, vitiligo, etc.), it would prove useful mainly in cases with a high risk of relapse [16]. The gene discussed is S100B; the disease is cardiovascular disorder.