Serum S100B protein is a moderately sensitive—61.35% (95% Confidence Interval (CI) (48.90, 73.80) and highly specific—87.30% (95% CI (81.10, 93.49)) melanoma recurrence biomarker, but because increased levels of S100B can result from several other conditions (cardiovascular disease, chronic kidney disease, liver cirrhosis, vitiligo, etc.), it would prove useful mainly in cases with a high risk of relapse [16]. Here, S100B is linked to cirrhosis of liver.