However, in the present study, it was observed that non-ulcerated MCTs had higher expression of RANK and CTLA-4, which contribute to the tumor immune cascade by recruiting regulatory T cells (Treg), followed by the silencing of CD8+ T cells associated with the release of CCL22 through mast cells and TAMs, contributing to the suppression of T cells through the expression of PD-L1 on the tumor cell membrane. This evidence concerns the gene CTLA4 and neoplasm.