As for the RANK/RANK-L proteins, a statistical difference (p = 0.049) was found when correlating the immunoreactivity of the RANK-L protein in the MCT tissue with tumor size, in which MCTs measuring more than 3 cm showed higher expression of this protein when compared to those smaller than 3 cm (Table 6, Figure 8) In addition, the absence of ulceration in the MCTs showed a statistical difference (p = 0.043) regarding the higher expression of the RANK protein compared to the group of MCTs with skin ulcerations (Table 6, Figure 7). The gene discussed is TNFRSF11A; the disease is Skin ulcer.