AKT1 and neuroblastoma: Świeszewska et al. examined activation of the PI3K pathway in 39 samples from patients with high-risk neuroblastoma and showed that expression of PI3Kp110 and PI3Kp85 could be detected in the cytoplasm of 54% of cases, and phosphorylated AKT was present in the cytoplasm in almost all cases [29].