AKT1 and neoplasm: The percentage of p-PI3K positive cells in tumor tissues was 83.5 ± 3.69%, 54 ± 8.75% (p = 0.042), 43 ± 15.85% (p = 0.006), and 31 ± 19.88% (p < 0.001) in the control, monensin rapamycin, and combination groups, respectively (Figure 4), while the number of cells expressing p-AKT in tumor tissues was 89 ± 4.7 in the control group, 63.5 ± 8.6% (p = 0.026), 45 ± 37.4% (p = 0.46), and 23.37% ± 13.21% (p = 0.006) in the monensin, rapamycin, and combination groups, respectively (Figure 4).