In addition to these findings, exosomes derived from MDA-MB-231 triple-negative BC and BT-474 luminal B BC cell lines, in a hypoxic environment, perform a potent immunosuppression activity by negatively modulating T cells proliferation through TGF-β and, accordingly, may influence in the immune system evasion process [110]. This evidence concerns the gene TGFB1 and breast cancer.