However, findings from our CRISPR/dCas9-Dnmt3a cell model suggest that the observed DNA methylation changes have antagonistic effects suggesting that we identified a mixture of stroke inducing (e.g., TRIM6 gene) as well as neuroprotective (e.g., TLN2 and FLRT2 genes) epigenetic biomarkers. The gene discussed is TLN2; the disease is Stroke.