On the other hand, as HAS3 under expression is associated with advanced tumor stage [50] and adverse pathological features in patients with urothelial carcinoma of upper urinary tract and urinary bladder [51], low BMSCs infiltration would be one of the causes if low infiltration of CD8+ T cells is a feature of urothelial carcinoma. This evidence concerns the gene CD8A and urothelial carcinoma.