Mice lacking Fam20c present the phenotype similar to human non-lethal Raine syndrome, including growth retardation, rickets/osteomalacia, defects in the growth plate, defective osteocytes differentiation, reduction of serum phosphate, and elevation of serum fibroblast growth factor (FGF23) [11]. This evidence concerns the gene FAM20C and lethal osteosclerotic bone dysplasia.