In primary and metastatic cancers, FOXM1 contributes to invasion, epithelial-mesenchymal transition (EMT) and metastasis through up-regulation of matrix metalloproteinase (MMP)-2, c-Met, pAKT, vimentin, and modulation of E-cadherin [17, 58] and related factors in breast tumors [59]. This evidence concerns the gene FOXM1 and breast neoplasm.