In our previous study, we discovered that Notch1 signaling controls the HMGB1/TLR4/NF-κB axis in AILI to regulate NLRP3 inflammasome activation, illuminating the critical function of the Notch1-Hes1 signaling cascade response in regulating innate immunity in APAP-triggered liver inflammation [16]. Here, NOTCH1 is linked to Hepatitis.