PTEN plays a pivotal role in controlling intracellular signaling for cell survival and proliferation by regulating the PI3K/Akt pathway [32], which is involved in many diseases, including hepatocellular carcinoma [33], liver fibrosis [34], liver ischemia and reperfusion injury [35] and DNA damage [36]. The gene discussed is PTEN; the disease is hepatocellular carcinoma.