Notably, the expression levels of all 3 genes and CRC tumor stage were closely related to the MEblue module (RP11-396E3.2, cor = 0.35, P = 2e−14; YBX1, cor = 0.47, P = 6e−26; STAT3, cor = 0.71, P = 3e−72; stage, cor = 0.11, P = 0.01), and MEgray module (RP11-396E3.2, cor = 0.39, P = 1e−17; YBX1, cor = 0.5, P = 3e−30; STAT3, cor = 0.58, P = 1e−41; stage, cor = 0.18, P = 2e−04). This evidence concerns the gene STAT3 and neoplasm.