CYP2J2-rs76271683 and CYP2C8-rs11572177 were associated with an increased risk of GDM (adjusted OR 1.27 [95% CI 1.07–1.49], 1.34[95% CI 1.07–1.67]; FDR = 0.028, 0.046, respectively). This evidence concerns the gene CYP2J2 and gestational diabetes.