In glioblastomas, cycle-dependent kinase 5 (CDK5) phosphorylates DRP1 at Ser616 and increases mitochondrial cleavage, which then induces the expression of stemness genes (OLIG2, OCT4, NANOG, NESTIN, POU3F2, CD133, SSEA1) [92] (Fig. 3B). Here, OLIG2 is linked to glioblastoma.