In glioblastomas, cycle-dependent kinase 5 (CDK5) phosphorylates DRP1 at Ser616 and increases mitochondrial cleavage, which then induces the expression of stemness genes (OLIG2, OCT4, NANOG, NESTIN, POU3F2, CD133, SSEA1) [92] (Fig. 3B). The gene discussed is POU3F2; the disease is glioblastoma.