While the majority of non-CGRP targets were able to induce migraine-like attacks with relatively high induction rates (Fig. 2), this was not the case for (i) calcium channels, as it is not yet possible to directly target channels to elucidate their precise involvement in migraine; (ii) TRP channels, activation of which can induce non-migraine headache; and (iii) ASICs, as their the potential in inducing migraine attacks has not been investigated thus far. The gene discussed is CALCA; the disease is migraine disorder.