We found that CRC patients with higher expression of MCM2 (HR = 0.093, 95% CI = 0.024–0.360, p = 0.001) and CGREF1 (HR = 0.104, 95% CI = 0.025–0.438, p = 0.002) had significantly better OS than those who had lower expression. The gene discussed is CGREF1; the disease is colorectal carcinoma.