In this study, by analyzing the clinical and transcriptome data of HCC in the Asian population downloaded from the TCGA database and human ARGs, 13 significant prognosis-related ARGs, namely, GNAI3, FKBP1A, BIRC5, SH3GLB1, HIF1A, RHEB, EIF2S1 RAB1A, ATIC, NPC1, PRKCD, ATG4B, and CLN3, were screened via multifactorial Cox regression analysis. Here, ATG4B is linked to hepatocellular carcinoma.