In this study, by analyzing the clinical and transcriptome data of HCC in the Asian population downloaded from the TCGA database and human ARGs, 13 significant prognosis-related ARGs, namely, GNAI3, FKBP1A, BIRC5, SH3GLB1, HIF1A, RHEB, EIF2S1 RAB1A, ATIC, NPC1, PRKCD, ATG4B, and CLN3, were screened via multifactorial Cox regression analysis. This evidence concerns the gene RHEB and hepatocellular carcinoma.