NLRP3 inflammasome activation-induced cytokine IL-1β is thought to be a key factor aggravating the inflammatory response [67] It is noteworthy that NLRP3 mutations appear to be specifically enhanced in neutrophils, with these cells being the primary source of IL-1β in severe CAPS, both in patients and in mouse models [68]. Here, IL1B is linked to cryopyrin-associated periodic syndrome.