Univariate logistic regression analysis revealed the following risk factors for severe COVID-19: advanced age; fever at the time of presentation; number of comorbidities; pre-existing cardiovascular disease; decreased albumin level; increased levels ofaspartate aminotransferase (AST), LDH, and lung CT score; increased red cell distribution width (RDW); thrombocytopenia, increasedplateletcrit, and platelet distribution width;hypocalcemia;and increased BNP and acute phase reactants(inflammatory markers) such as CRP, presepsin, and procalcitonin. The gene discussed is ALB; the disease is cardiovascular disorder.