PDE4D and intestinal disorder: He further speculated that this gene was a potential therapeutic target for inflammatory diseases, but it needed further verification [41, 42]. Chen et al., 2021 reported that PDE4D was crucial to the development of intestinal diseases by phosphorylating and activating the intestinal cell kinase.Given the high level of expression of SCIN in cancer tissues, we speculate that its expression level may also affect the diagnosis and prognosis of UC.Studies have found that SCIN also affects the colon's cellular immune infiltration.