Similarly, our MR analysis depicted that KIM-1 affects kidney function in individuals with diabetes mellitus through eGFRcrea (Beta = -0.016, 95%CI: -0.032 to -0.001, pSteiger_test < 0.0001) independently of disease duration (DN: OR = 0.914, 95%CI: 95%CI: 0.815 to 1.025). The gene discussed is HAVCR1; the disease is diabetes mellitus.