This process is mediated by transcription factors belonging to three distinct families: the Snail family (SNAIL1/SNAIL, SNAIL2/SLUG, and SNAIL3/SMUC), the Zeb family (ZEB1, ZEB2), and the b-HLH family (TWIST1, TWIST2) [31], as well as other factors that enhance cancer cell invasion through the crosstalk with the tumor microenvironment [32, 33]. This evidence concerns the gene SNAI2 and cancer.