In HNSCC, BRD4 recruits mediators and NF-κβ p65 to form super-enhancers at cancer stemness genes such as TP63, MET, and FOSL1, instead of MYC. Interestingly, the use of BET inhibitors disrupts the super-enhancers, eliminates cancer stem cells, and inhibits HNSCC invasive growth and metastasis [148]. This evidence concerns the gene TP63 and head and neck squamous cell carcinoma.