m6A-modified circCPSF6 is recognized and destabilized by YTHDF2, but circCPSF6 m6A demethylation by ALKBH5 facilitates the proliferation and metastasis of HCC cells via competitive interaction of circCPSF6 with PCBP2, activating the YAP1 signaling [283]. The gene discussed is YTHDF2; the disease is hepatocellular carcinoma.