PRMT5 and cervical carcinoma: In cervical cancer, PRMT5 (protein arginine N-methyltransferase 5) forms a complex with Snail, HDAC1/2, MTA1, Mep50, and NuRD, and represses the expression of TET1 and E-cadherin by histone methylation on their promoter regions, leading to EMT initiation and increased risk of metastasis [176].