Back to METTL3, its oncogenic activity has also been linked to tumor formation in CRC where m6A methylation of lncRP11 increases its nuclear accumulation, drives Siah1 and Fbxo45 mRNA degradation, and prevents ZEB1 mRNA decay, thus, regulating EMT and liver metastasis [222]. Here, METTL3 is linked to colorectal carcinoma.