To cite some metastasis-related examples of non-canonical functions of EZH2 beyond the polycomb complex, EZH2 promotes the transcriptional activation of the non-canonical NF-κB subunit RelB to drive self-renewal contributing to the maintenance of TNBC tumor initiating cells (TICs), cancer stem cells involved in tumor recurrence and metastasis [208]. The gene discussed is NFKB1; the disease is cancer.