MTOR and neoplasm: In addition, METTL1/WDR4-mediated m7G modification of tRNAs could promotes tumor progression and metastasis by enhancing the translation of a subset of oncogenic transcripts in HNSCC, including genes related to the PI3K/AKT/mTOR signaling pathway [299]; or by promoting the processing of miR-760 in an m7G modification-dependent way and indirectly degrading the tumor suppressor ATF3 mRNA via miR-760 in bladder cancer [300].