SIPA1L1 and gastric cancer: We inspected the 4Dgenome information of the 28 enhancers from the FANTOM5 database and found 10 of them were associated with a set of endogenous genes (Fig. 3B), including the ERRFI1, SLC45A1, PARK7, MIR3148, ZNF217, BCAS1, BMP7, DLEU7, DLEU1, DLEU2, SPTSSB, KLHL31, MIR205HG, SIPA1L1 and LINC00299. Interestingly, according to the data derived from The Cancer Genome Atlas program (TCGA), 12 out of the 15 enhancer-target genes (80%) were found aberrantly expressed in the gastric cancer cohort (375 tumors and 391 normal) (Fig. 3C).