High-risk population: single tumor diameter > 5 cm or 2–3 tumor nodules, the maximum tumor diameter ≤ 3 cm (BCLC A/CNLC Ib), with any of the following risk factors: 1 hepatic cirrhosis; 2 accompanied by ≥ 1 of the following serological changes: AFP 200–400 ng/mL, AFP-L3 5–10% and DCP 100–400 mAU/mL. Here, AFP is linked to Cirrhosis.