GPX4 and pancreatic adenocarcinoma: In Fig. 1A, most ferroptosis regulators were up-regulated in PAAD, including CDKN1A, HSPA5, SLC7A11, NFE2L2, HSPB1, GPX4, FANCD2, CISD1, FDFT1, SLC1A5, SAT1, TFRC, RPL8, NCOA4, DPP4, CS, ALOX15, and ACSL4 (P < 0.05), while the expression of LPCAT3, MT1G, and GLS2 was down-regulated in PAAD (P < 0.05).