NTHL1 and neoplasm: The estimation of cosine similarities between individual tumor mutational matrices and 60 COSMIC signatures showed that in addition to SBS5 (n = 14), SBS6 (n = 3) and SBS29 (n = 1), some samples had greater similarity to SBS3 (defective homologous recombination-based DNA damage repair, n = 3), SBS30 (deficiency in base excision repair due to inactivating mutations in NTHL1, n = 2), SBS40 (etiology: unknown, n = 5) and SBS94 (etiology: unknown, n = 1) (Fig. 3C).