The Bcl2/Bax ratio was 2.14 and 0.74 for 3xTg-CPE and 3xTg-GFP, respectively, indicating that hippocampal AAV-NF-α1/CPE treatment promotes cell survival in 3xTg-AD mice through modulating expression of these two mitochondrial membrane proteins [33]. The gene discussed is BCL2; the disease is Alzheimer disease.