Indeed, while GFAP immunostaining revealed no difference in glial cell numbers between 3xTg-GFP, 3xTg-CPE and non-Tg mice, CD11b/c, the microglia marker was significantly increased in the 3xTg-AD compared to non-Tg mice, indicative of neuroinflammation. This evidence concerns the gene ITGAM and Alzheimer disease.