Consistently, we found that ECM molecules, such as biglycan (BGN), chitinase 3 like 1 (CHI3L1), collagen type VI alpha 2 chain (COL6A2), fibronectin 1 (FN1), and matrilin 3 (MATN3), showed significantly higher expression in the corneal endothelial cells of patients with FECD than in non-FECD control subjects16. This evidence concerns the gene CHI3L1 and Fuchs endothelial corneal dystrophy.